“We need to know she’s alive.”

Four days after Nancy Guthrie’s disappearance, Savannah Guthrie made a tearful plea to her mother’s potential kidnappers.

On Wednesday, February 4, the Today host, 54, posted a video on Instagram of himself, his sister Annie, and brother Camron calling out their mother and Nancy’s potential kidnappers with the caption: “Bring her home.” “We have also heard reports in the media about ransom letters,” Savannah said. “We are doing the best we can as a family. We are ready to speak. But we live in a world where voices and images are easily manipulated. We need to know without a shadow of a doubt that she is alive and that you have her. We want and are ready to hear from you. Please contact us.”

Savannah went on to say that Nancy is “our heart and home,” before expressing concern about her mother’s health. “She’s 84 years old,” Savannah said. “Her health, her heart is fragile. She lives in constant pain. She has no medicine. She needs medicine to survive. She needs medicine not to suffer.”

Reflecting on how much her mother was loved and the support her family received, Savannah said, “On behalf of my family, I would like to thank everyone who has prayed for our beloved mother, Nancy. We feel that feeling, and we continue to believe that she feels it too. Our mother is a kind, loyal, fiercely loving woman of good and light. She has grandchildren who adore her and cover her with kisses. She loves fun and adventure, and is kind and knowledgeable.

“Mom, if you’re listening to this, you’re a strong woman,” Savannah added. “You are God’s precious daughter, Nancy. We believe and know that God is with you in this valley. Mom, we are looking for you everywhere. We will not rest, and your children will not rest until we are together again. We will always speak to you, pray without ceasing, and rejoice in advance of the day when we can hold you in our arms again. We love you.”

Annie says, “The light is going out from our lives. Nancy is our mother. We are her children. She is our lighthouse. She holds fast to joy in every situation in life. She chooses joy every day. Pain and pain.” Even though we have already gone through great trials of grief, we will always remain just human beings who need a mother. Mom, Mom, if you’re listening, I want you to come home. I miss you.

“We love you mom. Stay strong,” Camron concluded the video.

Nancy was reported missing from her Arizona home at 11 a.m. on Sunday, February 1, and an urgent missing person search is underway. According to the Pima County Sheriff’s Department (PCSD), she was last seen by her family around 9:30 p.m. local time on Saturday, January 31st.

Savannah shared her first public statement regarding the situation with her Today colleagues, who read it to her while she was absent from the show’s broadcast on Monday, February 2nd.

“On behalf of our family, I would like to thank everyone for your thoughts, prayers, and messages of support. At this time, our focus remains on the safe return of our beloved mother,” the anchor said.

The same day, Pima County Sheriff Chris Nanos provided an update on the investigation and the Guthrie family’s reaction in an interview with PEOPLE.

“They’re devastated, as is everyone. They’re family and they rely on each other,” he said, adding, “We’re just keeping in touch with them and they know this community supports them.”

He also claimed that he believed Nancy was taken “against her will.”

Also at a press conference on February 2, Nanos revealed that Nancy’s home was considered a “crime scene.” He also made a “plea”: “Anyone who knows anything about this, saw anything, heard anything, please contact us. Please call 911. We don’t need any more tragic endings. We need help.”

“This is an 84-year-old woman who has some physical ailments, some physical problems, and requires medication, which can be fatal if not taken within 24 hours,” Nanos said, noting that Nancy was of “very sound mind” and “did not leave on her own.”

Later that night, Savannah took to Instagram to ask for prayers for her mother and thank those who have shown support.

“We believe in prayer. We believe in voices raised in unison with love and hope. We believe in goodness,” Savannah wrote in the caption of her post. “We believe in humanity. And most of all, we believe in God.”

she continued. “Thank you for lifting up your prayers with us for our beloved mother, our beloved Nancy, a woman of deep faith, a good and faithful servant. Please lift up your prayers with us and believe with us that she will be lifted up by them in this moment.”

Savannah also quoted the Bible’s Isaiah 26:3, adding, “He will keep in perfect peace those who trust in him and whose hearts are steadfast. This is an Isaiah verse for all of us.”

“Take her home,” the caption concludes.

On Tuesday, February 3, PEOPLE confirmed that Savannah would no longer cover the 2026 Olympics, shortly after Nanos revealed that investigators still do not know where Nancy is and it is unclear how many people were involved in her kidnapping.

“Savannah will not be participating in the Olympics as she is focused on being with her family during this difficult time,” an NBC Sports spokesperson told PEOPLE in a statement. “Our thoughts are with her and the entire Guthrie family as the search for her mother continues. We will soon share additional information regarding our coverage plans for Opening Ceremony.”

Savannah was scheduled to co-host the ceremony in Milan, Italy on Friday, February 6th, with commentary from snowboarder Shaun White, along with Terry Gannon. Savannah’s former Today co-host Hoda Kotb will be in Milan during the event.

A source previously told PEOPLE that Savannah and her mother are “very, very close,” adding that they are “like best friends.”

“Savannah and her mom are crazy about each other,” another source told PEOPLE.

“Her mother means the world to her,” the source said. “Nancy’s face lights up every time she talks about Savannah.”

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Anyone with information is asked to contact the Pima County Sheriff’s Office at 520-351-4900. We recommend calling 88-CRIME or 520-882-7463. All calls remain anonymous. You can also use the mobile app P3TIPS or visit 88crime.org.